A Queens woman with special needs has gone missing from her relatives’ Bronx home, police say.

Marisol Delvalle, 46, who suffers from down syndrome, autism and a speech impediment went missing from the Arthur Avenue home Thursday morning.

Delvalle's extended family told police she was not happy staying in the Bronx while her immediate family was away, so she got upset and left.

She is described as being  4'9" tall and 145 pounds with straight, black hair.

She was last seen wearing a black, polka-dot shirt, a pink sweater, black pants and carrying a black bag.

Anyone with information is asked to call Crime Stoppers at 1-800-577-TIPS.